Vitamin B12 is the cofactor in enzymatic reactions with diverse physiological functions. It is required for the conversion of methylmalonyl CoA to succinyl CoA, as well as the conversion of homocysteine to methionine by methionine synthase, which is then converted into S-adenosylmethionine. A B12 deficiency causes impairments in both of these pathways, disrupting neurological function, including poor formation of myelin nerve sheaths, production of toxic levels of homocysteine, and inefficient energy production in all cells.
Cobalamin is also required to remove the methyl group from methyltetrahydrofolate and generate tetrahydrofolate, a necessary step in DNA synthesis. As a consequence, B12 deficiency affects the growth, function, and repair of all cells, the most apparent sign of which is megaloblastic anemia, caused by inhibited mitosis of red blood cells. Some individuals, especially those with malabsorption or low dietary intake, are at higher risks for a B12 deficiency. B12 in sublingual form, at a dose of 1000 mcg per day bypasses active absorption routes, and can restore normal B12 levels even in those with pernicious anemia and/or impaired absorptive capacity.
Serving Size: 1 Sublingual Tablet
Servings per Container: 60
Each Tablet Contains:
Vitamin B12 (Methylcobalamin)…………………………..1000 mcg or 5000 mcg
Lactose, microcrystalline cellulose, croscarmellose sodium, vegetable grade magnesium stearate (lubricant).
Contains no artificial preservatives, colour or sweeteners and no corn, soy, starch, wheat or yeast. Sealed for your protection. Do not use if seal is broken. For freshness, store in a cool, dry place.
1 tablet per day or as directed by a health care practitioner. Dissolve under the tongue. Keep out of reach of children.