Saccharomyces boulardii is a nonpathogenic yeast that has been used for the treatment of gastrointestinal disease in Europe since the 1960s. It has successfully decreased the duration of gastrointestinal disease associated with antibiotic use, Crohn's disease, and acquired immune-deficiency syndrome (AIDS).
Recent studies have shown S. boulardii's ability to stimulate host mucosal disaccharidase activity and enhance the intestinal mucosal immune response. These activities may be involved in the mechanism by which S. boulardii reduces the recurrence of C. difficile colitis
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